Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi.

摘要: The lack of antifungal drugs with novel modes action reaching the clinic is a serious concern. Recently protein referred to as Blad-containing oligomer (BCO) has received regulatory approval an agricultural agent. Interestingly its spectrum activity includes human pathogens such Candida albicans however mode yet be elucidated. Here we demonstrate that BCO exerts through inhibition metal ion homeostasis which results in apoptotic cell death C. albicans. HIP HOP profiling Saccharomyces cerevisiae using panel signature strains are characteristic for common identified hypersensitivity yeast lacking iron-dependent transcription factor Aft1 suggesting restricted iron uptake action. Furthermore, global transcriptome also disruption potential Experiments were carried out assess effect divalent ions on revealing antagonized by Mn2+, Zn2+ and Fe2+. profile implicated sterol synthesis possible secondary was subsequently confirmed assays Animal models toxicity showed generally well tolerated presents promising safety topical applied Given potent broad multi-target action, propose new agent treatment fungal infections.