Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors.
作者： Lorenzo Di Cesare Mannelli , Laura Micheli , Fabrizio Carta , Andrea Cozzi , Carla Ghelardini
DOI: 10.3109/14756366.2015.1113407
关键词:
摘要: Ischemia of brain areas is a global health problem, causing death or long-term disability. Current pharmacological options have limited impact on ischemic damages. Recently, relationship between hypoxia and carbonic anhydrase (CA) over-expression has been highlighted suggesting CA inhibition as possible target. This study aimed to evaluate the profile sulfonamide coumarin inhibitors in rats underwent permanent middle cerebral artery occlusion (pMCAO). The neurological score pMCAO was dramatically reduced 24 h after occlusion. Repeated subcutaneous injections 4 7 (1 mg kg(-1)) were able increase by 40%. Compound showed tendency reduce volume hemisphere infarction. standard inhibitor acetazolamide ineffective. properties novel improve functionalities insult are shown. involvement hypoxic phenomena deserves deeper investigations.
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