Cancer Targeting Gene-Viro-Therapy and Its Promising Future: A Trend in Both Cancer Gene Therapy and Cancer Virotherapy

摘要: The “Cancer Targeting Gene–Viro–Therapy, CTGVT,” strategy was initiated by us in 1999-2001, which constructed inserting an antitumor gene into oncolytic viral vector (OV), it is actually OV-gene therapy. CTGVT (OV-gene) shows much higher effect vitro and/or vivo than that of either respective therapy alone or virus alone. We have been persisted to study this for more 10 years and about 70 with rather high IF value papers published. order drugs OV-gene>OV≥Ad-gene. has recently become a hot topic the cancer field can be validated facts (1) Amgen paid 1 billion USD BioVex Inc. purchase product, OncoHSV-GM-CSF 205 (OV from herpes simplex virus); (2) OncoPox-GM-CSF (poxvirus) 206 published Nature 2011, because could intravenous administration targeted metastasize tumor. many modified complete eradication xenografted tumor as shown text. It will sure we make US paper’s OncoPox-GM-CSF.