The biological response to titanium and titanium-aluminium-vanadium alloy particles: II. Long-term animal studies

摘要: Abstract The long-term tissue reactions to participate titanium and titanium-aluminium-vanadium alloy were investigated by the intra-articular injection of material into knee joints mice. response was studied over a period 2 52 weeks. In general, both materials well tolerated, there no evidence necrosis only slight thickening synovium occurred around particles. Multinucleated giant cells rarely seen palpable tumours formed in any animal at site.