Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

摘要: Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral host genetic factors. Here we use human genome-wide genotyping arrays new whole-genome HCV sequencing technologies to perform a systematic genome-to-genome study 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles genes encoding leukocyte antigen molecules components the interferon lambda innate immune system drive polymorphism. Additionally, IFNL4 genotypes determine load through mechanism dependent specific amino acid residue in NS5A protein. These findings highlight interplay between genome control.