Effects of Antihistaminics on Experimental Brain Edema

摘要: Histamine has potent effects on cerebral blood vessels which include increased permeability and dilatation. Since its concentrations are found to be in brain tissue different experimental models of injury, histamine may act as a mediator secondary damage. Using the cold-lesion model vasogenic edema application antihistaminics were studied rats. Neither mepyramine, an H1 receptor blocker nor zolantidine, H2 provided any decrease swelling or water content. Experiments with dexamethasone yielded small non-significant while aminosteroid U74389F did not reduce swelling. The results indicate that is obviously involved mediating cold lesion-induced edema. Furthermore, generation lipid peroxides after activation phospholipase A2 also appears have significant influence present study.