Genetic alterations in cancer as a result of breakage at fragile sites
作者： Nicholas C Popescu
DOI: 10.1016/S0304-3835(02)00596-7
关键词:
摘要: Abstract The organization and replication of DNA render fragile sites (FSs) prone to breakage, recombination as well becoming preferential targets for mutagens–carcinogens integration oncogenic viruses. For many years, attempts link FSs cancer generated mostly circumstantial evidence. discoveries that chromosome translocations, amplification proto-oncogenes, deletion tumor suppressor genes, viruses all result from the specific breakage genomic at FSs, however, have provided compelling support such a link, further suggesting causative role in cancer.
elsevier.com
sci-hub.se 参考文章(134)
Marta Chesi, P. Leif Bergsagel, Oluwatoyin O. Shonukan, Maria Luisa Martelli, Leslie A. Brents, Theresa Chen, Evelin Schröck, Thomas Ried, W. Michael Kuehl, Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma Blood. ,vol. 91, pp. 4457- 4463 ,(1998) , 10.1182/BLOOD.V91.12.4457
Carlo M. Croce, Integration of Oncogenic Viruses in Mammalian Cells International Review of Cytology. ,vol. 71, pp. 1- 17 ,(1981) , 10.1016/S0074-7696(08)61180-8
R T Schimke, Gene amplification in cultured cells. Journal of Biological Chemistry. ,vol. 263, pp. 5989- 5992 ,(1988) , 10.1016/S0021-9258(18)68734-4
D. Zimonjic, T. Ried, H.M. Padilla-Nash, M.V.E. Macville, E. Schrock, N. Popescu, C. Keck, B.M. Ghadimi, Comprehensive and Definitive Molecular Cytogenetic Characterization of HeLa Cells by Spectral Karyotyping Cancer Research. ,vol. 59, pp. 141- 150 ,(1999)
Peter A. Jones, Stephen B. Baylin, The fundamental role of epigenetic events in cancer Nature Reviews Genetics. ,vol. 3, pp. 415- 428 ,(2002) , 10.1038/NRG816
Drazen B. Zimonjic, Teresa Druck, Nicholas C. Popescu, Kumar Kastury, Kay Huebner, Masataka Ohta, Carlo M. Croce, Positions of Chromosome 3p14.2 Fragile Sites (FRA3B) within the FHIT Gene Cancer Research. ,vol. 57, pp. 1166- 1170 ,(1997)
GR Sutherland, E Baker, The clinical significance of fragile sites on human chromosomes. Clinical Genetics. ,vol. 58, pp. 157- 161 ,(2001) , 10.1034/J.1399-0004.2000.580301.X
Avery A. Sandberg, The chromosomes in human cancer and leukemia ,(1990)
Ann W. Hoge, Charles M. Wilke, Ayla N. Adam, Susan L. Dagenais, David G. Beer, Thomas W. Glover, June E. Ascara-Wilke, Diane E. Miller, Herman A. Dierick, The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region Cancer Research. ,vol. 58, pp. 3409- 3414 ,(1998)
Joseph A. DiPaolo, Nicholas C. Popescu, Pedro A. Lazo, Amplification of the Integrated Viral Transforming Genes of Human Papillomavirus 18 and Its 5′-Flanking Cellular Sequence Located Near the myc Protooncogene in HeLa Cells Cancer Research. ,vol. 49, pp. 4305- 4310 ,(1989)