Sequential Cerebrospinal Fluid and Plasma Sampling in Humans: 24-Hour Melatonin Measurements in Normal Subjects and after Peripheral Sympathectomy
作者： JEFFREY BRUCE , LAWRENCE TAMARKIN , CHARLES RIEDEL , SANFORD MARKEY , EDWARD OLDFIELD
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摘要: Simultaneous measurements of plasma and cerebrospinal fluid (CSF) melatonin urinary excretion 6-hydroxymelatonin were performed in four normal volunteers one patient before after upper thoracic sympathectomy for the control essential hyperhidrosis. For individuals, hourly 24-h concentrations CSF exhibited similar profiles, with low levels during day high at night. Peak varied from 122–660 pmol/L, peak 94–355 pmol/L. The onset nocturnal increase did not occur same time each individual. Urinary also a daily rhythm, individual lowest circulating had 6-hydroxymelatonin. In hyperhidrosis, prominent rhythm was observed preoperatively plasma. After bilateral T1-T2 ganglionectomy, however, leve...
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