Sulpiride and Other Benzamides as Specific Antagonists at the D2 Dopamine Receptor

摘要: Publisher Summary This chapter discusses sulpiride and other benzamides as specific antagonists at the D2 dopamine receptor. Sulpiride is a substituted benzamide, similar to metoclopramide it possesses pronounced antiemetic activity. strong inhibitory effects on apomorphine-induced vomiting in dogs potent stimulant of prolactin release both laboratory animals man. The presents vitro vivo investigation interaction with (DA) neurotransmitter receptors molecular level. reliability these studies has been strengthened by use stereoselectivity agonist antagonist compounds research tool. Brain homogenates or slices were prepared according standard procedure effect some chemically-related derivatives determined stimulation cyclic adenosine monophosphate (AMP) formation elicited DA. also comparison ability that various agonists displace binding 3H-Haloperidol from rat striatal membrane preparation..