Cardiac Memory Is Associated With Decreased Levels of the Transcriptional Factor CREB Modulated by Angiotensin II and Calcium
作者： Kornelis W. Patberg , Alexei N. Plotnikov , Aaron Quamina , Ravil Z. Gainullin , Andrew Rybin
DOI: 10.1161/01.RES.0000088785.24381.2F
关键词:
摘要: Cardiac memory (CM) has short- (STCM) and long-term (LTCM) components modulated by calcium angiotensin II. LTCM is associated with reduced Ito Kv4.3 mRNA levels. Because the cAMP response element binding protein, CREB, contributes to CNS transcription, we hypothesized that it might be a transcriptional factor in CM, influenced We studied STCM dogs were AV sequentially paced (AVP) for 2 hours or sham-operated. was evaluated ECG vectorcardiogram (VCG), subepicardial biopsies taken at 5 120 minutes investigated CREB. 3 weeks sham controls. At heart excised, obtained, CRE tested. induction occurred AVP but not treated saralasin nifedipine. Nuclear CREB significantly decreased no-drug group only. manifested of nuclear proteins CRE, activity promoter region Kv4.3. In conclusion, there an association between angiotensin-modulated calcium-dependent. Moreover, after combined can explain downregulation characterize LTCM.
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