Phosphorylase kinase mediating the effects of cyclic AMP in muscle

摘要: In the classic view of control phosphorylase b to a conversion by catecholamines, cyclic AMP acts as second messenger stimulating activity AMP-dependent protein kinase covalently modify kinase. Phosphorylation converts this enzyme form with nonactivated an activated markedly higher at pH 7. There is now considerable evidence that phospphorylase also regulated changeds in Ca-2+ concentration. The both and stimulated range concentrations have been reported occur sacroplasm contracting muscle, pphosphorylase having lower K-alpha for Ca-2+. Thus there are leaset two mechanisms regulation muscle. These may act independently or concert controlling glycogenolysis anoxia, tetanic electrical stimulation...