Challenging Mycobacterium tuberculosis dormancy mechanisms and their immunodiagnostic potential

摘要: Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one world's greatest cause morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed its high level adaptation as a host pathogen. Prior become dormant, group about 50 genes related metabolic changes are transcribed by DosR regulon, most complex important systems host-pathogen interaction. This genetic mechanism allows mycobacteria persist during long time periods, establishing so-called latent infection. Even in presence competent immune response, cannot eliminate pathogen, only managing keep it surrounded an unfavorable microenvironment for growth. However, conditions such immunosuppression may reestablish optimal bacterial growth, culminating onset active The interactions between pathogen still not completely elucidated. Nonetheless, many studies being carried out order clarify this relationship, thus creating new possibilities patient approach laboratory screening.