Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy

摘要: Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer. The 2-year survival rate of patients with stage III or IV disease only about 50%. Due to its high radiosensitivity, radiotherapy the standard treatment for early-stage NPC. However, radioresistance observed in some can cause distant metastases and local recurrence after radiotherapy. Special emphasis has been given discovery effective radiosensitizers. Oncogenic proteins encoded by EBV genomes may serve as part targeted radiosensitization, such NF кB-mediated expression latent membrane protein-1. We here review major nucleic acid-based options currently used cancer therapeutic approaches selected candidate genes that be NPC radiosensitization.