Genetic polymorphism of cytochrome P4502E1 in a Swedish population : relationship to incidence of lung cancer
作者： Irene Persson , Inger Johansson , Helene Bergung , Marja-Liisa Dahl , Janeric Seidegård
DOI: 10.1016/0014-5793(93)80547-8
关键词:
摘要: Genetic polymorphism of CYP2E1 was investigated among 195 Swedish patients with lung cancer and 206 controls. Three different polymorphic sites were found, all in introns, using RFLP the restriction enzymes DraI, RsaI TaqI. The frequencies rare alleles 0.08–0.18 much lower than previously described Japanese. No significant difference distribution between controls evident, contrast to results a previous Japanese study. However, examination site 5'-flanking region, within putative binding motif for hepatic transcription factor HNF-1, revealed significantly less frequent mutated allele (c2) as compared It is concluded that major interethnic differences exist genetic people carrying c2 might be at risk developing cancer.
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