A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery.

摘要: This quantitative systematic review compared the efficacy and safety of ephedrine with phenylephrine for prevention treatment hypotension during spinal anesthesia cesarean delivery. Seven randomized controlled trials (n 292) were identified after a search electronic databases (MEDLINE, EMBASE, The Cochrane Controlled Trials Registry), published articles, contact authors. Outcomes assessed maternal hypotension, hypertension bradycardia, neonatal umbilical cord blood pH values Apgar scores. For management (prevention treatment) there was no difference between (relative risk [RR] 1.00; 95% confidence interval [CI], 0.96 –1.06). Maternal bradycardia more likely to occur than (RR 4.79; CI, 1.47–15.60). Women given had neonates higher arterial those (weighted mean 0.03; 0.02– 0.04). There two vasopressors in incidence true fetal acidosis (umbilical value 7.2; RR 0.78; 0.16 –3.92) or score of7 at 1 5 min. does not support traditional idea that is preferred choice elective delivery healthy, nonlaboring women. (Anesth Analg 2002;94:920 –6)