Estimating the Global Incidence of Aneurysmal Subarachnoid Hemorrhage: A Systematic Review for Central Nervous System Vascular Lesions and Meta-Analysis of Ruptured Aneurysms

摘要: Introduction There is increasing acknowledgement that surgical care important in global health initiatives. In particular, neurosurgical as limited 1 per 10 million people parts of the world. We performed a systematic literature review to examine worldwide incidence central nervous system vascular lesions and meta-analysis aneurysmal subarachnoid hemorrhage (aSAH) define disease burden inform efforts. Methods A were conducted according Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines estimate epidemiology lesions, including unruptured ruptured aneurysms, arteriovenous malformations, cavernous dural fistulas, developmental venous anomalies, vein Galen malformations. Results organized by World Health Organization regions. After review, because lack data from particular regions, we determined could only provide an aSAH. Using studies with aSAH 12 high-quality stroke regions lacking data, meta-analyzed yearly crude 100,000 persons. Estimates generated via random-effects models. From initial yield 1492 studies, 46 manuscripts on included. The final included 58 31 different countries. estimated be 6.67 persons wide variation across WHO 0.71 12.38 Conclusions Worldwide, almost 500,000 individuals will suffer each year, two-thirds low- middle-income