Immunocompetent cells from the lower respiratory tract of normal human lungs.

摘要: Subpopulations of lymphocytes in the broncho-alveolar air spaces normal human lungs were compared with those peripheral blood. Bone marrow-derived (bursal-equivalent) cells (B cells) identified by complement receptors (EAC rosettes) and surface immunoglobulin. Thymus-derived (T their proliferative response to mitogens E rosette technique. Cells lung recovered from eight healthy nonsmoking volunteers segmental lavage flexible bronchofiberscope. On average, macrophages constituted 78% 17% aspirates. B detected immunoglobulin equaled 22% 15% lymphocytes, respectively. The distribution into heavy chain classes revealed IgM IgG be predominant classes, mean values 14.5% 9.3%, respectively; corresponding value for IgA was 5%. A comparable order frequency (IgM greater than IgA) observed purified blood same other control subjects. T comprised majority (47%) identifiable method. presence also corroborated (phytohemagglutinin concanavallin A), but less that equal numbers B/T cell ratio results subjects, a higher proportion could not as either or cells. It is postulated participate local immune defenses lung.