Suppression of experimental allergic encephalomyelitis by interferon.
作者： Sergio L. Abreu
DOI: 10.3109/08820138209050718
关键词:
摘要: Experimental allergic encephalomyelitis (EAE) is an experimental, T-cell dependent, autoimmune disease of the central nervous system that can be induced in most mammals by injection myelinated neural tissue complete Freund's adjuvant. Relatively small doses, 10(4.6) Units/kg, rat interferon (IFN), specific activity 10(7.6) delayed onset and significantly ameliorated severity EAE symptoms observed Lewis rats. Injection IFN at 10(5.6) U/Kg suppressed hind limb paralysis 70 to 80%
informahealthcare.com参考文章(24)
Ruth Arnon, Experimental allergic encephalomyelitis--susceptibility and suppression. Immunological Reviews. ,vol. 55, pp. 5- 30 ,(1981) , 10.1111/J.1600-065X.1981.TB00337.X
N. K. Gonatas, J. C. Howard, Inhibition of Experimental Allergic Encephalomyelitis in Rats Severely Depleted of T Cells Science. ,vol. 186, pp. 839- 841 ,(1974) , 10.1126/SCIENCE.186.4166.839
Marie-Anne Bach, Elizabeth Tournier, Francoise Phan-Dinh-Tuy, Lucienne Chatenoud, Jean-Francois Bach, Claude Martin, Jean-Denis Degos, Deficit of suppressor T cells in active multiple sclerosis. The Lancet. ,vol. 316, pp. 1221- 1223 ,(1980) , 10.1016/S0140-6736(80)92480-0
D. A. Stringfellow, L. A. Glasgow, Tilorone Hydrochloride: an Oral Interferon-Inducing Agent Antimicrobial Agents and Chemotherapy. ,vol. 2, pp. 73- 78 ,(1972) , 10.1128/AAC.2.2.73
Jules Freund, Murray M. Lipton, Allergic encephalomyelitis in the rat induced by the intracutaneous injection of central nervous system tissue and adjuvants. Journal of Immunology. ,vol. 71, pp. 98- 109 ,(1953)
H. M. Johnson, G. J. Stanton, S. Baron, Relative ability of mitogens to stimulate production of interferon by lymphoid cells and to induce suppression of the in vitro immune response. Experimental Biology and Medicine. ,vol. 154, pp. 138- 141 ,(1977) , 10.3181/00379727-154-39622
H Heremans, A Billiau, A Colombatti, J Hilgers, P de Somer, Interferon treatment of NZB mice: accelerated progression of autoimmune disease. Infection and Immunity. ,vol. 21, pp. 925- 930 ,(1978) , 10.1128/IAI.21.3.925-930.1978
A S Kadish, F A Tansey, G S Yu, A T Doyle, B R Bloom, Interferon as a mediator of human lymphocyte suppression. Journal of Experimental Medicine. ,vol. 151, pp. 637- 650 ,(1980) , 10.1084/JEM.151.3.637
S. Levine, R. Sowinski, Synergistic suppression of the hyperacute form of experimental allergic encephalomyelitis by tilorone and cycloleucine. Experimental Biology and Medicine. ,vol. 156, pp. 457- 460 ,(1977) , 10.3181/00379727-156-39956
H. Megel, A. Raychaudhuri, S. Goldstein, C. R. Kinsolving, I. Shemano, J. G. Michael, Tilorone: its selective effects on humoral and cell-mediated immunity. Experimental Biology and Medicine. ,vol. 145, pp. 513- 518 ,(1974) , 10.3181/00379727-145-37842