Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix.

摘要: We and others previously reported that equimolar doses of methamphetamine cocaine differentially increase preprodynorphin mRNA in striatum: causes a patchy increase, whereas produces more homogenous one. The current study directly examined whether this effect reflects differential induction the patch–matrix division striatum, as identified by µ opioid receptor immunohistochemistry. In addition, we determined (30 mg/kg) (2 mg/kg) produced equivalent increases extracellular dopamine affected expression striatum male, Sprague–Dawley rats. both experiments, after 3 h. high, dose selectively increased patch rostral throughout matrix divisions striatum. contrast, (2.0 mg/kg) caused an similar to 30 mg/kg did not significantly affect any region These data provide further evidence amphetamines exert distinct effects on suggest post-synaptic consequences elevated are distinct.