Asymmetric synthesis of potent glycosidase and very potent α-mannosidase inhibitors: 4-amino-4-deoxy-l-erythrose and 4-amino-4,5-dideoxy-l-ribose
作者： Jean-Bernard Behr , Carine Chevrier , Albert Defoin , Céline Tarnus , Jacques Streith
DOI: 10.1016/S0040-4020(02)01512-0
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摘要: Abstract Pyrrolidine amino-sugars, cyclic iminoalditols as well linear aminoalditols in 4-amino- l -erythrose and 4-amino-5-deoxy- -ribose series were synthesised by asymmetric hetero-Diels–Alder reaction followed chemical transformations. 4-Amino-4-deoxy- 4-amino-4,5-dideoxy- potent β- d -glucosidase, α- -mannosidase, -galactosidase inhibitors. We have shown that the ribose derivative was a very inhibitor of -mannosidase.
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