Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin.

摘要: In this series of papers it has been shown that the immune response mice to sheep erythrocytes requires participation two classes lymphoid cells. Thymus-derived cells initially react with antigen and then interact another class cells, antibody-forming cell precursors, cause their differentiation Antilymphocyte globulin depressed ability respond erythrocytes. This effect was more marked when injected intraperitoneally than intravenously, occurred only antilymphocyte given before or simultaneously antigen. Injection thymus restored near normal an intravenous injection Spleen from globulin-treated gave a weak adoptive in irradiated recipients. The addition however enabled similar by spleen When thymectomized recipients were used, continued give higher challenge at 2 4 wk postirradiation did ALG-treated donors. result is consistent notion thymus-derived target are eliminated, rather temporarily inactivated, globulin. These findings suggest that, vivo, acts selectively on antigen-reactive