Biochemical Characteristics of 8-Azaguanine Resistant Human Lymphoblast Mutants Selected in Vitro

作者: G. Nuki , J. Lever , J. Edwin Seegmiller

DOI: 10.1007/978-1-4684-3294-7_31

关键词:

摘要: Much of recent progress in our understanding the regulation purine metabolism man has resulted from vitro studies on cells patients with inborn errors (1, 2).

参考文章(24)
F M Rosenbloom, J F Henderson, I C Caldwell, W N Kelley, J E Seegmiller, Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase. Journal of Biological Chemistry. ,vol. 243, pp. 1166- 1173 ,(1968) , 10.1016/S0021-9258(19)56968-X
George H. Rothblatt, Vincent J. Cristofalo, Growth, nutrition, and metabolism of cells in culture ,(1972)
William N. Kelley, Jean C. Meade, Studies on Hypoxanthine-Guanine Phosphoribosyltransferase in Fibroblasts from Patients with the Lesch-Nyhan Syndrome Journal of Biological Chemistry. ,vol. 246, pp. 2953- 2958 ,(1971) , 10.1016/S0021-9258(18)62275-6
R. J. Albertini, R. DeMars, Diploid azaguanine-resistant mutants of cultured human fibroblasts. Science. ,vol. 169, pp. 482- 485 ,(1970) , 10.1126/SCIENCE.169.3944.482
P. Coffino, R. Laskov, M. D. Scharff, Immunoglobulin production: method for quantitatively detecting variant myeloma cells Science. ,vol. 167, pp. 186- 188 ,(1970) , 10.1126/SCIENCE.167.3915.186
W. Y. Fujimoto, J. E. Seegmiller, Hypoxanthine-guanine phosphoribosyltransferase deficiency: activity in normal, mutant, and heterozygote-cultured human skin fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 65, pp. 577- 584 ,(1970) , 10.1073/PNAS.65.3.577
Robert DeMars, Karsten R. Held, The spontaneous azaguanine-resistant mutants of diploid human fibroblasts. Human Genetics. ,vol. 16, pp. 87- 110 ,(1972) , 10.1007/BF00393992
WILLIAM N. KELLEY, Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Gout Annals of Internal Medicine. ,vol. 70, pp. 155- 206 ,(1969) , 10.7326/0003-4819-70-1-155
Jay A. Levy, Martti Virolainen, Vittorio Defendi, Human lymphoblastoid lines from lymph node and spleen Cancer. ,vol. 22, pp. 517- 524 ,(1968) , 10.1002/1097-0142(196809)22:3<517::AID-CNCR2820220305>3.0.CO;2-A