Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis.

摘要: OBJECTIVE: To determine the prevalence and correlates of neuropsychological impairment in a large cohort (n = 146) patients with typical, sporadic (non-familial) amyotrophic lateral sclerosis. METHODS: A battery tests was administered to sclerosis who were attending monthly outpatient clinic or hospital undergoing diagnostic tests. RESULTS: Comparing individual patient's scores relevant normative data, 35.6% displayed evidence clinically significant impairment, performing at below 5th percentile on least two eight measures. Deficits most common areas problem solving, attention/mental control, continuous visual recognition memory, word generation, verbal free recall. Impairment prevalent dysarthria (48.5%), but 27.4% non-dysarthric also impaired. Impaired had more severe widespread symptoms than non-impaired patients, fewer years education. CONCLUSION: Neither conventional wisdom that cognition is intact nearly all sclerosis, nor recent suggestions often mildly impaired seems be correct. minority impairment. Dysarthria, low education, greater severity motor risk factors for