miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2.
作者： Wang Li , Xu Cui , Anlong Qi , Lihui Yan , Tong Wang
DOI: 10.1016/J.PRP.2019.152636
关键词:
摘要: Abstract Background Gastric cancer (GC) is the fourth most prevalent malignant tumor and second leading cause of cancer-related death around world. Aberrant proliferation metastasis are mainspring in patients with GC. However, specific mechanism gastric far from being fully elucidated. Accumulating evidence revealed that miRNA played a significant role tumorigenesis development. Methods The level miR-183-5p was detected 102 GC by using qRT-PCR. prognostic value evaluated. Cell function assays (CCK-8 transwell assays) were conducted to assess Dual luciferase report assay western blot performed validate this potential target regulated Results down-regulated tissues cell lines. Remarkable pertinence obtained between TNM stage, size, invasion depth, lymph node metastasis. differentiation independent causes impacting on overall survival multivariate analysis. individuals high would experience relatively better prognosis. Upregulation restrained migration. EEF2 may be gene Conclusion acts as biomarker regulates functions modulating EEF2.
sci-hub.se 参考文章(35)
Ya-nan Wang, Fang Xu, Pei Zhang, Pan Wang, Ya-ning Wei, Chen Wu, Shu-jie Cheng, MicroRNA-575 regulates development of gastric cancer by targeting PTEN Biomedicine & Pharmacotherapy. ,vol. 113, pp. 108716- ,(2019) , 10.1016/J.BIOPHA.2019.108716
Leonie Mönkemeyer, Courtney L. Klaips, David Balchin, Roman Körner, F. Ulrich Hartl, Andreas Bracher, Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2 Molecular Cell. ,vol. 74, pp. 88- 100.e9 ,(2019) , 10.1016/J.MOLCEL.2019.01.034
Ying Kong, Liang Ning, Fei Qiu, Qian Yu, Bin Cao, Clinical significance of serum miR-25 as a diagnostic and prognostic biomarker in human gastric cancer. Criminal Behaviour and Mental Health. ,vol. 24, pp. 477- 483 ,(2019) , 10.3233/CBM-182213
Fei Jiang, Xiaobing Shen, Current prevalence status of gastric cancer and recent studies on the roles of circular RNAs and methods used to investigate circular RNAs. Cellular & Molecular Biology Letters. ,vol. 24, pp. 53- ,(2019) , 10.1186/S11658-019-0178-5
Mingjiu Chen, Jian Chen, [Serum levels of miRNA-183 in patients with esophageal squamous cell carcinoma and its diagnostic value]. Journal of Central South University. Medical sciences. ,vol. 43, pp. 1048- 1053 ,(2018) , 10.11817/J.ISSN.1672-7347.2018.10.002
D Chen, S-G Li, J-Y Chen, M Xiao, MiR-183 maintains canonical Wnt signaling activity and regulates growth and apoptosis in bladder cancer via targeting AXIN2. European Review for Medical and Pharmacological Sciences. ,vol. 22, pp. 4828- 4836 ,(2018) , 10.26355/EURREV_201808_15618
Dawei Yuan, Kang Li, Kun Zhu, Rong Yan, Chengxue Dang, Plasma miR-183 predicts recurrence and prognosis in patients with colorectal cancer. Cancer Biology & Therapy. ,vol. 16, pp. 268- 275 ,(2015) , 10.1080/15384047.2014.1002327
Jan Bornschein, Michael Selgrad, Maren Warnecke, Doerthe Kuester, Thomas Wex, Peter Malfertheiner, H. pylori infection is a key risk factor for proximal gastric cancer. Digestive Diseases and Sciences. ,vol. 55, pp. 3124- 3131 ,(2010) , 10.1007/S10620-010-1351-X
LANG XU, YUHONG LI, DAN YAN, JUN HE, DAN LIU, MicroRNA-183 inhibits gastric cancer proliferation and invasion via directly targeting Bmi-1. Oncology Letters. ,vol. 8, pp. 2345- 2351 ,(2014) , 10.3892/OL.2014.2504
Sirjana Shrestha, Sheng‐Da Hsu, Wei‐Yun Huang, Hsi‐Yuan Huang, WenLiang Chen, Shun‐Long Weng, Hsien‐Da Huang, A systematic review of microRNA expression profiling studies in human gastric cancer. Cancer Medicine. ,vol. 3, pp. 878- 888 ,(2014) , 10.1002/CAM4.246