Cortical atrophy is relevant in multiple sclerosis at clinical onset.

摘要: Increasing evidence suggests relevant cortical gray matter pathology in patients with Multiple Sclerosis (MS), but how early this begins; its impact on clinical disability and which areas are primarily affected needs to be further elucidated. 115 consecutive (10 Clinically Isolated Syndrome (CIS), 32 possible MS (p-MS), 42 Relapsing Remitting (RR-MS), 31 Secondary Progressive (SP-MS)), 40 age/gender-matched healthy volunteers (HV) underwent a neurological examination 1.5 T MRI. Global regional Cortical Thickness (CTh) measurements, brain parenchyma fraction T2 lesion load were analyzed. We found significant global thinning p-MS (2.22 ± 0.09 mm), RR-MS (2.16 0.10 mm) SP-MS (1.98 0.11 compared CIS (2.51 HV (2.48 0.08 mm). The correlations between mean CTh white (WM) was only moderate (r = )0.393, p 0.03) absent )0.147, 0.422). Analysis of revealed that the majority involved not MS, also p-MS. type picture at onset (in particular, pyramidal signs/symptoms optic neuritis) correlated atrophy corresponding areas. is diffuse phenomenon already detectable onset. It correlates partially independent from WM inflammatory pathology.