Helminth- and Bacillus Calmette-Guérin-Induced Immunity in Children Sensitized In Utero to Filariasis and Schistosomiasis

摘要: Infants and children are routinely vaccinated with bacillus Calmette-Guerin (BCG) in areas of the world where worm infections common. Because maternal helminth infection during pregnancy can sensitize developing fetus, we studied whether this prenatal immunity persists childhood modifies immune response to BCG. Children newborns living rural Kenya, BCG is administered at birth filariasis schistosomiasis endemic, were examined. T cells from 2- 10-year-old mothers without or produced 10-fold more IFN-γ mycobacterial purified protein derivative than helminth-infected ( p < 0.01). This relationship was restricted because status did not correlate filarial Ag-driven IL-2, IFN-γ, IL-4, IL-5 responses by children. Prospective studies initiated showed that helminth-specific cell acquired utero maintained until least 10–14 mo age absence either Wuchereria bancrofti Schistosoma haematobium . Purified derivative-driven production evaluated after vaccination 26-fold higher for infants who sensitized filariae schistosomes relative subjects experienced sensitization These data indicate gestation persist into biases induced away type 1 associated protection against infection.