Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin.

摘要: The purpose of this review is to illustrate the application molecular methodologies investigation a fundamentally integrative problem in renal physiology, namely, mechanism regulation water excretion by kidney and concomitant concentration solutes urine. A new revolution physiology occurring as research tools have become available result cloning cDNAs for many major transporters receptors medulla. Among important medullary are aquaporin channels, which mediate osmotic transport across epithelia. One these aquaporin-2, has been shown be target short-term collecting duct permeability vasopressin. In addition, two aquaporin-2 aquaporin-3, targets long-term vasopressin through effects on absolute expression levels channel proteins. This focuses mechanisms both short- channels