Large scale spatial and temporal genetic diversity of feline calicivirus.

摘要: Feline calicivirus (FCV) is an important pathogen of domestic cats and a frequently used model human caliciviruses. Here we use epidemiologically rigorous sampling framework to describe for the first time phylodynamics at regional national scales. A large number FCV strains cocirculated in United Kingdom community levels, with no strain comprising more than 5% 14% these populations, respectively. The majority exhibited relatively restricted geographical range, only two (one field virus one vaccine virus) spreading further 100 km. None were identified outside Kingdom. Temporally, while some persisted locally study, others may have become extinct. Evolutionary analysis revealed radial phylogeny little bootstrap support nodes above level. In most cases, spatially temporally diverse intermingled phylogeny. Together, data suggest that current evolution not associated selective competition among strains. Rather, genetic antigenic landscape each location highly complex, many cocirculating. These variants likely exist level by combination de novo occasional gene flow from wider population. This complexity provides benchmark, time, against which cross-protection both local levels can be judged.