Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers

摘要: The oxidative modification of low density lipoprotein (LDL) may play a role in the pathogenesis atherosclerosis. Furthermore, evidence oxidized LDL (ox-LDL) has been found vivo. Supplementation some animal models with antioxidants shown to retard formation aortic Ascorbate (vitamin C) is highly potent aqueous-phase antioxidant plasma, which vitro oxidation. Cigarette smokers have reduced concentrations ascorbate their and be more prone Hence, objective present study was examine effect depletion supplementation on propensity oxidize 6-week study. Nineteen healthy followed diet (< or = 30 mg/day) for 2 weeks, then were randomly assigned receive placebo 1000 mg per day 4 weeks. Blood taken at 0 weeks susceptibility. 5 mumol/l copper. ascorbate-supplemented group had significant increases plasma ascorbate. showed no change time course oxidation between However, reduction susceptibility as measured by thiobarbituric acid-reactive substances (TBARS) conjugated dienes. demonstrated significantly increased lag phase decreased rate compared No changes group. biochemical signs consistent body iron stores. otherwise resulted