Effects of large variations in diet on free catecholamines and their metabolites in urine

摘要: Abstract Urinary excretion of free catecholamines and their major metabolites was studied in seven normal young men while they were on three diets which excessive, moderately restricted, or very low catecholamine nad caffeine content. When results are expressed relation to urinary creatinine, the most liberal diet increased normetanephrine ( NM ) VMA excreation by about 30 per cent. Free epinerphrine E metaphrine M rates also 40 cent 10 cent, respectively, but changes not statistically significant. Changes norepinerphrine NE dopamine D small did approach statistical significance. as quantities excreted day, only significant differene associated with greater during restricted diet. Intra-subject variation estimated creatinine arge, a median coefficient 16 amines unit intrasubject variance made smaller not. This “creatinine correction” tended enhance significance intersubject differences. The more increase variance, particularly . Variance least affected. Except for , where it roughly equal effects, much than effects. It is concluded that studies attention must be given content In involving shoudl proscribed controlled. case probably no control appears necessary.