Effect of concentration and degree of saturation on co-precipitation of catechin and poly(l-lactide) by the RESOLV process

摘要: Abstract Rapid expansion of subcritical solutions into liquid solvents (RESOLV) was able to consistently produce catechin (CTC)-loaded poly( l -lactide) (PLLA) nanoparticles. The effects CTC concentration and processing conditions – pre-expansion temperature pressure, degree saturation on the size morphology CTC-loaded PLLA nanoparticles were investigated, as well loading capacity (LC), entrapment efficiency (EE), release CTC. RESOLV experiments carried out with 0.1 wt% CTC + 0.2 wt% 0.2 wt% in mixtures EtOH CO 2 (3:2, wt/wt) pressure 60–100 °C 265–325 bar, respectively. obtained spherical, average sizes, LC, EE ranges ∼30–40 nm, 2.4–7.3%, 4.7–22.0%, concentration, temperature, had significant LC CTC, without affecting composite increased increasing saturation, decreasing concentration. profiles from exhibited an initial stage burst (first 8 h) followed by a sustained (∼1–9 days). Furthermore, fraction being released decreased prior rapid