N-acetylcysteine for the prevention of contrast-induced nephropathy in patients with pre-existing renal insufficiency or diabetes: a systematic review and meta-analysis.
作者： Xin Kang , Da-Yong Hu , Chang-Bin Li , Zi-Sheng Ai , Ai Peng
DOI: 10.3109/0886022X.2015.1012985
关键词:
摘要: AbstractPurpose: To identify benefit of N-acetylcysteine (NAC) on patients with pre-existing renal insufficiency or diabetes. Background: NAC administration is a common method for prevention contrast-induced nephropathy (CIN). Nevertheless, its diabetes remains uncertain and controversial. Methods: Randomized controlled trials (RCTs) to evaluate the efficacy CIN in were searched from databases MEDLINE, EMBASE, Cochrane library. Pooled odds ratio (OR) 95% confidence interval (95% CI) calculated using fixed-effects model by Mantel–Haenszel test. Results: Twenty RCTs involving 3466 subjects (1756 assigned 1710 control) included dysfunction group. analysis suggested significant reduction among this group (OR, 0.76; CI, 0.61–0.93; p = 0.008). However, nine...
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