Inauhzin Sensitizes p53-Dependent Cytotoxicity and Tumor Suppression of Chemotherapeutic Agents

摘要: Toxicity and chemoresistance are two major issues to hamper the success of current standard tumor chemotherapy. Combined therapy agents with different mechanisms action is a feasible effective means minimize side effects avoid resistance chemotherapeutic drugs while improving antitumor effects. As most essential suppressor, p53 or its pathway has been an attractive target develop new type molecule-targeting anticancer therapy. Recently, we identified small molecule, Inauhzin (INZ), which can specifically activate by inducing deacetylation. In this study, tested if combination INZ could sensitize cells drugs, cisplatin (CIS) doxorubicin (DOX). We found that compared any single treatment, lower doses CIS DOX significantly promoted apoptosis cell growth inhibition in human non-small lung cancer colon lines p53-dependent fashion. This cooperative effect between on suppression was also confirmed xenograft model. Therefore, study suggests targeting enhance sensitivity markedly reduce chemotherapy, possibly decreasing adverse