Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy

摘要: Purpose To assess clinical outcomes and complications in patients with non–small-cell lung cancer (NSCLC) treated helical tomotherapy (HT) or without chemotherapy. Methods Materials Data from 37 NSCLC between January 2007 August 2008 were analyzed retrospectively. Twenty-eight had Stage III disease. Concurrent neoadjuvant chemotherapy was given to 24 14 patients, respectively. Radiotherapy delivered a total dose of 60–70.4 Gy at 2.0–2.4 per fraction the gross tumor volume 50–64 1.8–2.0 planning target volume. Results With median follow-up 18 months (range, 6–27 months), 2-year local control overall survival rates 63% 56% for all respectively, 78% 75% disease who received concurrent chemoradiotherapy alone. Acute esophagitis treatment-related pneumonitis (TRP) ≥Grade 3 occurred 5 7 Four died death (TRD) after HT. In univariate analysis, poor performance status, V , contralateral (CL) 10 associated TRD. Only CL remained significant multivariate analysis ( p = 0.029). Conclusions HT has shown promising outcomes, esophagitis, TRPs. However, produced somewhat high rate fatal pulmonary complications. Our data suggest that should be considered kept as low possible