Novel formulation strategies for the fabrication of lyophilised orally disintegrating tablets

摘要: Orally disintegrating Tablets (ODTs), also known as fast-disintegrating, fast-melt or fast-dissolving tablets, are a relatively novel dosage technology that involves the rapid disintegration dissolution of form into solution suspension in mouth without need for water. The containing active ingredients is swallowed, and then absorbed through gastrointestinal epithelium to reach target produce desired effect. Formulation ODTs was originally developed address swallowing difficulties conventional solid oral forms (tablets capsules) experienced by wide range patient population, especially children elderly. current work investigates formulation development prepared freeze drying. Initial studies focused on parameters influence manufacturing process performance lyophilised tablets based excipients used commercial products (gelatin saccharides). second phase followed up comprehensive essential create saccharide free using naturally accruing amino acids individually combinations. Furthermore, factorial design study carried out investigate feasibility delivering multiparticulate systems challenging drugs exploited electrostatic associative interaction between gelatin carrageenan. Finally, aimed replace with ethically morally accepted components end users were performed selected binder optimise ODT formulations incorporated varies physicochemical properties. Our results show elegant instant adequate mechanical strength requires carful optimisation concentration bloom addition type concentration. Successful saccharides crystallise frozen state display high Tg', interact integrate completely and, also, short wetting time medium. use an optimised mixture gelatin, carrageenan alanine able viscous solutions suspend at same provide times On other hand, gum arabic showed outstanding potential ODTs. Compared formulations, simplified stages, shortened drying cycles produced superior terms strength. capability deliver diverse advantages over products.