GI transit of potential bioadhesive formulations in man: A scintigraphic study
作者： D. Harris , J.T. Fell , H.L. Sharma , D.C. Taylor
DOI: 10.1016/0168-3659(90)90182-S
关键词:
摘要: Abstract It is known that the oral availability of certain drugs can be limited by residence time dose in upper GI tract. Among methods proposed to delay transit pharmaceutical formulations use bioadhesion. In this work, gastric emptying and small intestinal some potentially adhesive were studied man gamma scintigraphy. Two different capsule investigated, combination with two bioadhesive polymers a non-adhesive control. Small differences oro-caecal seen combinations, but no dramatic effects on observed.
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