An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam.

作者: Marcel C. A. Buster , Giel H. A. van Brussel , Wim van den Brink

DOI: 10.1046/J.1360-0443.2002.00179.X

关键词:

摘要: Aims It has been suggested that starting and temporarily discontinuing methadone treatment is related to an increased risk in overdose mortality. This study describes the incidence of mortality relation time after (re)entering or leaving treatment. Design A dynamic cohort 5200 Amsterdam clients was observed during (a maximum 1 year) treatment. Findings Between 1986 1998, 29 729 person-years (py) 68 deaths were recorded, leading rate 2.3/1000 py (2.2 2.4 treatment). modest increase first 2 weeks treatment; 6.0/1000 py (rate ratio: 2.9; 95% confidence interval 1.4; 5.8). Directly no observed. Conclusions Inhaling heroin, common among heroin users, thought account for low OD rates both treatment. Accumulation methadone, inadequate assessment tolerance known re-entering concurrent periods stress extreme use when entering are mentioned as possible explanations within weeks. An Australian reported a much higher increase. The explained by background mortality, dosage threshold

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