Sildenafil Citrate for Prophylaxis of Nephropathy in an Animal Model of Contrast-Induced Acute Kidney Injury

摘要: Contrast-induced acute kidney injury (CIAKI) is one of the commonest complications associated with contrast media (CM). Although exact etiology CIAKI remains unclear, hypothesis involves vasoconstriction afferent arterioles resulting in renal ischemia. Increased blood flow, therefore, might represent an attractive target for treatment CIAKI. In this study we evaluated protective effects phosphodiesterase type 5 (PDE5) inhibitor, sildenafil citrate, a rabbit model New Zealand white rabbits were used due to their susceptibility To evaluate sildenafil, drug was administered before CM infusion and repeatedly throughout remainder experiment (6 mg/kg, p.o.). Animals sacrificed after 48 hours kidneys prepared histological evaluation. Intravenous administration produced marked injury. Serum creatinine concentrations elevated within two remained duration experiment. Histological evaluation revealed significant tubular necrosis. The dose dependent. Treatment lesser degree injury, attenuation markers (48 hour 1.54±0.21 versus 4.42±1.31 mg/dl, p<0.05) reduction electrolyte derangement (percent change serum K+ at 2.55±3.80% 15.53±4.47%, p<0.05; Na+ −0.14±0.26% −1.97±1.29%, p = 0.20). results suggest possible role PDE5 inhibitors warrant further determine mechanism protection.