Side and time variability of intraepidermal nerve fiber density
作者： G. Lauria , P. Dacci , R. Lombardi , D. Cazzato , C. Porretta-Serapiglia
DOI: 10.1212/WNL.0000000000001666
关键词:
摘要: Objective: To assess the right-to-left and short-term variability of intraepidermal nerve fiber density (IENFD) at distal site leg. Methods: Patients with possible or probable small neuropathy (SFN) healthy volunteers (HVs) underwent skin biopsies right left A subgroup participants follow-up 20 days later. Biopsies were immunostained by polyclonal anti-protein gene product 9.5 antibodies, IENFD was quantified in nonconsecutive sections following published guidelines operators blinded to participants9 condition (diagnosis, side, time biopsy). Findings referred sex- age-adjusted normative values. Results: Forty patients 17 HVs bilateral biopsies; 15 8 biopsies. Sural dorsal sural conduction studies normal all participants. Interside did not differ both (median 2.45 IENF/mm ± 1.45 SD right; 2.2 1.32 left) 6.3 2.81 6.2 2.3 left). The correlation coefficients excellent (Pearson 0.95 SFN 0.97 HVs). analysis 20-day biopsy showed no difference between sides groups yielded coefficients. Conclusions: diagnosis can be reliably ascertained unilateral leg, is expected vary within 3 weeks.
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