Scope and limitations of the synthesis of functionalized quinolizidinones and related compounds by a simple precursor approach via addition of lithium allylmagnesates to 2-pyridones and RCM as key steps

摘要: Abstract The scope and limitations of the simple synthesis functionalized quinolizidin-4-ones by chemoselective N-alkenylation NH pyridin-2(1H)-ones (2-pyridones), regioselective addition lithium allyl(di-n-butyl)magnesates(1-) to N-alkenylpyridin-2(1H)-ones, followed ring closing metathesis (RCM) is described. A number functionalizations introduced into quinolizidin-4-one rings demonstrated high prospect strategy proposed in scaffold synthesis. Their extension syntheses pyrido[1,2-a]azepin-4-one pyrido[1,2-a]azocin-4-one derivatives as well spiro-fused compounds also presented.