Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls.

摘要: Abstract Objective The goal of this study was to characterize types, frequency, combinations, and relative onset symptoms among ovarian cancer cases controls. Methods Participants were from an ongoing, population-based, case–control primary epithelial in a 48-country region North Carolina. Incident ( N = 267), aged 20–74, identified by area hospitals on rapid case ascertainment basis between April 1999 March 2001. Population-based controls, with at least one intact ovary, frequency matched age race, using random-digit dialing 287) Health Care Financing Administration (HCFA) phone lists 30). Trained nurse-interviewers, standardized questionnaire, asked participants about specific experienced for 2 weeks the year prior diagnosis (cases)/interview (controls). Results More than 90% reported symptom most often reason doctor visit leading (74%), followed routine examination (12%). Among invasive cases, onsets longer before (median 5–7 months) included gas/nausea/indigestion; urinary frequency/urgency; bowel irregularity; abnormal menstrual/vaginal bleeding or discharge; pain during intercourse; ongoing fatigue. Symptoms closer 2–4 distended/hard abdomen; bloating/feeling fullness; unexplained weight gain/loss; pelvic/abdominal discomfort; chest pain/respiratory difficulties; "other" symptoms. Controls fewer 1 vs 5 6). Control duration much less likely occur combination. Conclusion Earlier may be possible if women physicians recognize importance combinations seemingly unrelated symptoms, especially those as occurring diagnosis.