Retracted: microRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells
作者： Jing-Hua Wang , Le Zhang , Yu-Wei Ma , Jing Xiao , Yi Zhang
关键词:
摘要: The function of retinoic acid-inducible gene-I (RIG-I) in viral replication is well documented, but its carcinogenesis and malignancies as relationship with microRNAs (miRNAs) remain poorly understood. miR-34a an antioncogene multiple tumors. In our study, RIG-I suppressed cell growth, proliferation, migration, invasion cervical cancer cells vitro. was validated a new regulator by binding to 3' untranslated region upregulating expression level. Furthermore, we revealed that enhanced apoptosis, delayed the G1/S/G2 transition cycle, inhibited epithelial-mesenchymal process modulate cells. Phenotypic rescue experiments indicated mediates effects HeLa C33A These findings provide insights into mechanisms underlie may biomarkers for diagnosis therapy cancer.
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