Association between 25(OH)D Level, Ultraviolet Exposure, Geographical Location, and Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis.

摘要: Background There is no consensus on the vitamin D levels and inflammatory bowel disease (IBD). Aim To conduct a systematic review meta-analysis to analyze relationship between IBD 25(OH)D, sun exposure, latitude, determine whether deficiency affects severity of IBD. Methods We searched PubMed, EBSCO, ClinicalTrials.gov databases identify all studies that assessed association through November 1, 2014, without language restrictions. Studies compared 25(OH)D patients controls were selected for inclusion in meta-analysis. We calculated pooled standardized mean differences (SMDs) odds ratios (ORs). Results Thirteen case-control investigating CD included, eight part above also investigated UC 25(OH)D. Both (SMD: 0.26 nmol/L, 95% confidence interval [CI]: 0.09–0.42 nmol/L) 0.5 CI: 0.15–0.85 had lower than controls. In addition, 1.95 times (OR, 1.95; CI, 1.48–2.57) 2.02 2.02; 1.13–3.60) more likely be deficient included 10 activity D. Results showed with active (CD Activity Index≥150) have low levels. exposure high latitude related morbidity need provided evidence. Conclusion Our study shows For patients, low. These findings suggest may play an important role development IBD, although direct could not determined our study.