Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application.

摘要: The enhancing effect of several fatty acids from different subclasses: saturated (lauric acid), mono-unsaturated (oleic acid) and poly-unsaturated (linoleic linolenic acids) in the percutaneous absorption piroxicam was investigated. These were applied on skin membrane three ways: included vehicle, as a pretreatment or both. An increase flux value found for lauric oleic following order: with 5% followed by application gels containing acids>skin control gel>gel without pretreatment. For linoleic acids, two experiments almost same, although higher than when formulation. Skin acid propylene glycol gel acid, showed highest capacity. After lag time values decreased nearly times compared to those obtained same amount retained after be very similar all 3-fold