The Efficacy and Safety of Tadalafil 5 mg Once Daily in the Treatment of Erectile Dysfunction After Robot-Assisted Laparoscopic Radical Prostatectomy: 1-Year Follow-up.
作者： Young Eun Seo , Soo Dong Kim , Tae Hyo Kim , Gyung Tak Sung
DOI: 10.4111/KJU.2014.55.2.112
关键词:
摘要: Purpose: To evaluate the efficacy and safety of tadalafil 5 mg once daily use in treatment erectile dysfunction (ED) after robot-assisted laparoscopic radical prostatectomy (RALP). Materials Methods: The study retrospectively evaluated 92 patients who underwent RALP at Dong-A University Hospital. were surveyed by abridged five-item version International Index Erectile Function (IIEF-5) questionnaire, which was self-administered before surgery 6 months 1 year surgery. classified into group (n=47) non-tadalafil (n=45). Each then depending on nerve-sparing (NS) procedure used: bilateral NS or unilateral NS. Results: At months, total IIEF-5 scores 10.0±3.4 7.0±4.0, respectively. year, score significantly greater than that (13.2±5.6 vs. 7.7±4.8, p＜0.0001). Statistically significant improvements (p＜0.05) observed for all domains score, whereas there no improvement any year. reported side effects flushing (8.5%, n=4), headache (4.3%, n=2), dizziness (2.1%, n=1). Conclusions: In ED RALP, a once-daily dose well tolerated improved EF compared with group.
sci-hub.se 参考文章(28)
Culley C Carson, Michael J Kennelly, Brian P DeFade, Postprostatectomy erectile dysfunction: the role of penile rehabilitation. Reviews in urology. ,vol. 13, pp. 6- 13 ,(2011)
John P. Mulhall, Abraham Morgentaler, Controversies in Sexual Medicine: Penile Rehabilitation Should Become the Norm for Radical Prostatectomy Patients The Journal of Sexual Medicine. ,vol. 4, pp. 538- 543 ,(2007) , 10.1111/J.1743-6109.2007.00486.X
Georgios Megas, Georgios Papadopoulos, Georgios Stathouros, Dimitrios Moschonas, Ioannis Gkialas, Konstantinos Ntoumas, Comparison of efficacy and satisfaction profile, between penile prosthesis implantation and oral PDE5 inhibitor Tadalafil therapy, in men with nerve-sparing radical prostatectomy erectile dysfunction BJU International. ,vol. 112, pp. E169- E176 ,(2013) , 10.1111/J.1464-410X.2012.11561.X
Francesco Montorsi, Antonio Aversa, Ignacio Moncada, Petros Perimenis, Hartmut Porst, Clare Barker, Michael A. Shane, Sebastian Sorsaburu, A Randomized, Double‐Blind, Placebo‐Controlled, Parallel Study to Assess the Efficacy and Safety of Once‐A‐Day Tadalafil in Men with Erectile Dysfunction Who Are Naïve to PDE5 Inhibitors The Journal of Sexual Medicine. ,vol. 8, pp. 2617- 2624 ,(2011) , 10.1111/J.1743-6109.2011.02353.X
JinQiu Yuan, RenJie Zhang, ZuYao Yang, Jack Lee, YaLi Liu, JinHui Tian, XiWen Qin, ZhengJia Ren, Hong Ding, Qing Chen, Chen Mao, JinLing Tang, Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis European Urology. ,vol. 63, pp. 902- 912 ,(2013) , 10.1016/J.EURURO.2013.01.012
Hartmut Porst, Jacob Rajfer, Adolfo Casabé, Robert Feldman, David Ralph, Luiz F. Vieiralves, Anne Esler, Anne M. Wolka, Suzanne R. Klise, Long-Term Safety and Efficacy of Tadalafil 5 mg Dosed Once Daily in Men with Erectile Dysfunction The Journal of Sexual Medicine. ,vol. 5, pp. 2160- 2169 ,(2008) , 10.1111/J.1743-6109.2008.00935.X
Konstantinos Hatzimouratidis, Arthur L. Burnett, Dimitrios Hatzichristou, Andrew R. McCullough, Francesco Montorsi, John P. Mulhall, Phosphodiesterase Type 5 Inhibitors in Postprostatectomy Erectile Dysfunction: A Critical Analysis of the Basic Science Rationale and Clinical Application European Urology. ,vol. 55, pp. 334- 347 ,(2009) , 10.1016/J.EURURO.2008.10.028
Gwen Lagoda, Sena F. Sezen, Tongyun Liu, Ahmet Höke, Arthur L. Burnett, FK506-binding protein localizations in human penile innervation BJU International. ,vol. 101, pp. 604- 609 ,(2008) , 10.1111/J.1464-410X.2007.07290.X
Hartmut Porst, François Giuliano, Sidney Glina, David Ralph, Adolfo R. Casabé, Albert Elion-Mboussa, Wei Shen, J. Steve Whitaker, Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5 mg and 10 mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial European Urology. ,vol. 50, pp. 351- 359 ,(2006) , 10.1016/J.EURURO.2006.02.052
Rupesh Raina, Milton M Lakin, Ashok Agarwal, Rakesh Sharma, Kush K Goyal, Drogo K Montague, Eric Klein, Craig D Zippe, Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up. Urology. ,vol. 62, pp. 110- 115 ,(2003) , 10.1016/S0090-4295(03)00157-2