Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6.
作者： Akiyuki Uzawa , Masahiro Mori , Kimihito Arai , Yasunori Sato , Sei Hayakawa
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摘要: Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.Objective: To investigate the contribution of cytokines/chemokines pathogenesis NMO.Methods: We measured 27 Th17 cell-associated cerebrospinal fluid (CSF) 31 NMO, 29 MS 18 other non-inflammatory neurological disorders patients. The serum levels some cytokines/ were also measured. correlations between clinical characteristics/laboratory findings examined.Results: CSF interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 granulocyte colony-stimulating factor significantly increased while IL-9, fibroblast growth factor-basic, macrophage factor, inflammatory protein-1-beta tumor necrosis factor-alpha MS. IL-10...
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