Effect of intracoronary nicorandil administration on preventing no-reflow/slow flow phenomenon during rotational atherectomy.

摘要: A major limitation of the rotational atherectomy (RA) procedure is occurrence no-reflow/slow flow phenomenon and optimal strategy still evolving. Recent clinical studies have demonstrated beneficial effects nicorandil, an adenosine triphosphate (ATP)-sensitive potassium channel opener, on no-reflow in patients with acute myocardial infarction. The purpose this study was to evaluate effect nicorandil during RA procedures. Sixty-one who underwent complex coronary lesions were randomly divided into 2 groups: (i) cocktail (n=24 patients, 37 lesions) (ii) verapamil (n=37 63 lesions). In each group, drug mixed pressurized saline infused through 4Fr Teflon sheath rotablator system procedure. consisted 24 mg 5 nitroglycerin, 10,000 U heparin. 10 verapamil, Baseline characteristics did not differ between groups. performed successfully, death, Q-wave infarction, or emergency artery bypass surgery occur any patients. observed 11/63 (17.4%) but only 1/37 (2.7%) group (p=0.03). No untoward complications infusion. These data indicate that intracoronary continuous infusion procedures easy safe, prevents more effectively than verapamil. (Circ J 2002; 66: 1119 - 1123)