摘要: 2-Bromopropane (2BP, isopropyl bromide), a substitute for freon, has recently been suspected to be the causative chemical outbreak of some reproductive dysfunctions such as amenorrhea and oligospermia in workers who exposed this solvent an electronic factory. Bacterial mutation assays, chromosome aberration analysis vitro, micronucleus tests vivo, were carried out clarify mutagenicity 2BP. 2BP induced Salmonella typhimurium TA100 with metabolic activation dose-dependant manner. TA1535 well, or without activation. These observations indicated that base-pair substitution type mutations strains. The showed negative results Chinese hamster lung cells treated different concentrations, ranging from 0.077 2.46 mg/ml 6 h 24 frequencies recorded by examining polychromatic erythrocytes bone marrows rats which intraperitoneally injected 28 days. There was no significant increase at any doses (125 mg/ kg b.w./day, 250 mg/kg 500 b.w./day). However, comparison controls, there decrease percentage total number erythrocytes. This suggests may marrow depression hematopoiesis these dose levels Despite hematopoietic inhibition marrow, formation induced.
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