Multi-Institutional Validation of the Predictive Value of Ki-67 Labeling Index in Patients With Urinary Bladder Cancer

摘要: Several small single-center studies have reported a prognostic role for Ki-67 labeling index in advanced urothelial carcinoma of the urinary bladder. To investigate whether was useful biomarker oncological outcome after radical cystectomy carcinoma, we assessed its expression tumor tissue from 713 patients treated with and bilateral lymphadenectomy at six centers. A high independently associated established features aggressive disease recurrence, cancer-specific survival. Addition improved accuracy standard multivariate prediction models, as measured by Harrell concordance index, 2.9% recurrence 2.4% bladder cancer – specific survival ( P < .001, two-sided Mantel Haenszel) — statistically potentially clinically significant margin. In conclusion, routine assessment status along other predictors has potential to improve identification who are increased risk progression thus may benefit perioperative systemic chemotherapy.