Pathogenic factors of vibrios with special emphasis on Vibrio vulnificus

摘要: Bacteria of the genus Vibrio are normal habitants aquatic environment and play roles for biocontrole ecosystem, but some species believed to be human pathogens. These can classified into two groups according types diseases they cause: gastrointestinal infections extraintestinal infections. The pathogenic produce various factors including enterotoxin, hemolysin, cytotoxin, protease, siderophore, adhesive factor, hemagglutinin. We studied vibrios with special emphasis on protease hemolysin V. vulnificus. vulnificus is now recognized as being among most rapidly fatal pathogens, although infection appeared in patients having underlying disease(s) such liver dysfunction, alcoholic cirrhosis or haemochromatosis. (VVP) thought a major toxic factor causing skin damage septicemia. VVP metalloprotease degrades number biologically important proteins elastin, fibrinogen, plasma proteinase inhibitors complement components. causes damages through activation Factor XII-plasma kallikrein-kinin cascade and/or exocytotic histamine release from mast cells, haemorrhagic lesion digestion vascular basement membrane. Thus, probable candidate tissue bacterial invasion during an infection. Pathogenic functional mechanism other hemolysins mimicus also shown this review article.